| November 15, 2027 | MCNEESE STATE COWBOYS | L 67-80 | 0-1 | B. McClintock 18 | B. Lam 6 | W. McCoy 10 |
| November 18, 2027 | @ Louisiana State Fighting Tigers | L 64-87 | 0-2 | J. Lawson 18 | J. Lawson 6 | W. McCoy 7 |
| November 22, 2027 | INCARNATE WORD CARDINALS | W 86-80 OT | 1-2 | B. Lam 19 | J. Lawson 9 | A. Ford 9 |
| November 25, 2027 | @ Northwestern Wildcats ESPN Events Invitational | W 71-57 | 2-2 | M. Rhodes 18 | J. Lawson 8 | M. Rhodes 9 |
| November 26, 2027 | @ #9 West Virginia Mountaineers ESPN Events Invitational | L 57-75 | 2-3 | B. Lam 17 | J. Lawson 8 | W. McCoy 8 |
| November 29, 2027 | WESTERN MICHIGAN BRONCOS | W 81-65 | 3-3 | W. McCoy 17 | J. Lawson 6 | T. Calhoun 7 |
| December 2, 2027 | @ Illinois State Redbirds | L 78-92 | 3-4 | B. Lam 22 | J. Lawson 5 | W. McCoy 8 |
| December 6, 2027 | CENTRAL MICHIGAN CHIPPEWAS | W 86-79 | 4-4 | B. Lam 23 | J. Lawson 10 | M. Rhodes 8 |
| December 13, 2027 | CORNELL BIG RED | W 73-59 | 5-4 | J. Lawson 20 | J. Lawson 6 | W. McCoy 16 |
| December 20, 2027 | TEXAS A&M-COMM. LIONS | W 88-71 | 6-4 | B. Lam 26 | J. Lawson 9 | W. McCoy 10 |
| December 26, 2027 | @ Clemson Tigers* | L 61-73 | 6-5 | B. Lam 17 | J. Lawson 8 | M. Rhodes 9 |
| December 28, 2027 | @ #11 North Carolina Tar Heels* | L 60-70 | 6-6 | B. Lam 13 | J. Lawson 5 | W. McCoy 7 |
| January 2, 2028 | WAKE FOREST DEMON DEACONS (7-4, 1-1, 0-1 Away)* | - | | | | |
| January 4, 2028 | @ Pittsburgh Panthers (10-4, 0-2, 7-1 Home)* | - | | | | |
| January 9, 2028 | LOUISVILLE CARDINALS (11-2, 2-0, 2-0 Away)* | - | | | | |
| January 11, 2028 | @ Syracuse Orange (3-8, 0-2, 3-7 Home)* | - | | | | |
| January 16, 2028 | STANFORD CARDINAL (10-3, 1-1, 0-1 Away)* | - | | | | |
| January 18, 2028 | @ Florida State Seminoles (8-5, 0-2, 6-2 Home)* | - | | | | |
| January 23, 2028 | NOTRE DAME FIGHTING IRISH (7-5, 2-0, 2-1 Away)* | - | | | | |
| January 25, 2028 | DUKE BLUE DEVILS (9-4, 2-0, 1-2 Away)* | - | | | | |
| January 30, 2028 | @ California Golden Bears (8-3, 2-0, 6-2 Home)* | - | | | | |
| February 1, 2028 | VIRGINIA TECH HOKIES (7-4, 2-0, 1-1 Away)* | - | | | | |
| February 6, 2028 | MIAMI (FL) HURRICANES (6-5, 0-2, 0-4 Away)* | - | | | | |
| February 8, 2028 | @ Southern Methodist Mustangs (5-7, 0-2, 4-4 Home)* | - | | | | |
| February 13, 2028 | VIRGINIA CAVALIERS (12-1, 2-0, 4-1 Away)* | - | | | | |
| February 15, 2028 | @ NC-State Wolfpack (5-6, 0-2, 5-5 Home)* | - | | | | |
| February 20, 2028 | GEORGIA TECH YELLOW JACKETS (10-3, 1-1, 1-3 Away)* | - | | | | |
| February 22, 2028 | SOUTHERN METHODIST MUSTANGS (5-7, 0-2, 0-2 Away)* | - | | | | |
| February 27, 2028 | @ Virginia Cavaliers (12-1, 2-0, 5-0 Home)* | - | | | | |
| March 1, 2028 | @ Wake Forest Demon Deacons (7-4, 1-1, 7-2 Home)* | - | | | | |
