| November 13, 2027 | ST. THOMAS TOMMIES | W 63-58 | 1-0 | L. Fletcher 15 | J. Curry 3 | E. Xavier 9 |
| November 15, 2027 | TOLEDO ROCKETS | L 90-96 OT | 1-1 | C. Cole 18 | J. Curry 3 | E. Xavier 10 |
| November 18, 2027 | LOYOLA MARYMOUNT LIONS | W 65-43 | 2-1 | L. Fletcher 12 | J. Curry 5 | E. Xavier 13 |
| November 22, 2027 | MOREHEAD STATE EAGLES | W 85-64 | 3-1 | J. Curry 17 | L. Fletcher 4 | B. Hedrick 9 |
| November 25, 2027 | PRINCETON TIGERS | W 81-60 | 4-1 | L. Fletcher 14 | J. Curry 5 | B. Hedrick 6 |
| November 29, 2027 | TENNESSEE STATE TIGERS | W 81-70 | 5-1 | C. Cole 17 | J. Curry 5 | D. McFall 8 |
| December 2, 2027 | MISSISSIPPI VALLEY DELTA DEVILS | W 80-68 | 6-1 | J. Curry 17 | J. Curry 4 | L. Fletcher 7 |
| December 6, 2027 | MORGAN STATE BEARS | W 68-66 | 7-1 | J. Curry 13 | J. Curry 4 | E. Xavier 14 |
| December 13, 2027 | STONY BROOK SEAWOLVES | L 70-78 | 7-2 | J. Curry 14 | E. Xavier 3 | C. Cole 7 |
| December 20, 2027 | GEORGETOWN HOYAS | L 66-73 | 7-3 | C. Cole 12 | J. Curry 4 | D. McFall 7 |
| December 26, 2027 | BOSTON COLLEGE EAGLES* | W 73-61 | 8-3 | L. Fletcher 19 | C. Cole 5 | E. Xavier 11 |
| December 28, 2027 | @ Virginia Tech Hokies* | L 51-65 | 8-4 | J. Curry 14 | J. Curry 3 | E. Xavier 7 |
| January 2, 2028 | @ Florida State Seminoles* | L 66-70 | 8-5 | J. Curry 16 | G. Peterson 4 | D. McFall 10 |
| January 4, 2028 | CALIFORNIA GOLDEN BEARS* | W 76-54 | 9-5 | J. Curry 22 | C. Cole 4 | D. McFall 10 |
| January 9, 2028 | NOTRE DAME FIGHTING IRISH* | L 67-78 | 9-6 | C. Cole 17 | J. Curry 2 | D. McFall 7 |
| January 11, 2028 | SOUTHERN METHODIST MUSTANGS* | L 63-74 | 9-7 | J. Curry 10 | L. Fletcher 3 | C. Cole 6 |
| January 16, 2028 | WAKE FOREST DEMON DEACONS* | W 87-72 | 10-7 | B. Hedrick 13 | C. Cole 5 | B. Hedrick 8 |
| January 18, 2028 | @ Syracuse Orange* | W 78-59 | 11-7 | L. Fletcher 20 | L. Fletcher 4 | D. McFall 7 |
| January 23, 2028 | #8 DUKE BLUE DEVILS* | W 72-64 | 12-7 | C. Cole 14 | J. Curry 5 | C. Cole 6 |
| January 25, 2028 | @ NC-State Wolfpack* | W 65-52 | 13-7 | J. Curry 18 | C. Cole 4 | D. McFall 8 |
| January 30, 2028 | #12 NORTH CAROLINA TAR HEELS* | L 73-74 | 13-8 | J. Curry 13 | C. Cole 3 | E. Xavier 10 |
| February 1, 2028 | @ Stanford Cardinal* | L 62-70 | 13-9 | J. Curry 14 | J. Curry 3 | D. McFall 13 |
| February 6, 2028 | #8 LOUISVILLE CARDINALS* | W 78-68 | 14-9 | D. McFall 15 | J. Curry 5 | B. Hedrick 10 |
| February 8, 2028 | @ #21 Georgia Tech Yellow Jackets* | L 59-71 | 14-10 | G. Peterson 12 | J. Lee 5 | D. McFall 13 |
| February 13, 2028 | @ #14 Pittsburgh Panthers* | L 55-61 | 14-11 | D. McFall 13 | J. Curry 4 | D. McFall 13 |
| February 15, 2028 | @ Miami (FL) Hurricanes* | L 68-88 | 14-12 | L. Fletcher 13 | J. Curry 5 | C. Cole 5 |
| February 20, 2028 | @ #9 Virginia Cavaliers* | L 60-75 | 14-13 | G. Peterson 13 | J. Curry 3 | D. McFall 10 |
| February 22, 2028 | #16 GEORGIA TECH YELLOW JACKETS* | L 62-82 | 14-14 | C. Cole 18 | J. Curry 5 | E. Xavier 5 |
| February 27, 2028 | @ California Golden Bears* | W 85-75 | 15-14 | L. Fletcher 19 | C. Cole 5 | D. McFall 7 |
| March 1, 2028 | STANFORD CARDINAL* | L 64-74 | 15-15 | C. Cole 10 | J. Curry 4 | E. Xavier 10 |
| March 8, 2028 | @ Southern Methodist Mustangs ACC Tournament | L 61-74 | 15-16 | C. Cole 13 | J. Curry 4 | D. McFall 9 |
