| November 13, 2027 | ST. THOMAS TOMMIES | W 63-58 | 1-0 | L. Fletcher 15 | J. Curry 3 | E. Xavier 9 |
| November 15, 2027 | TOLEDO ROCKETS | L 90-96 OT | 1-1 | C. Cole 18 | J. Curry 3 | E. Xavier 10 |
| November 18, 2027 | LOYOLA MARYMOUNT LIONS | W 65-43 | 2-1 | L. Fletcher 12 | J. Curry 5 | E. Xavier 13 |
| November 22, 2027 | MOREHEAD STATE EAGLES | W 85-64 | 3-1 | J. Curry 17 | L. Fletcher 4 | B. Hedrick 9 |
| November 25, 2027 | PRINCETON TIGERS | W 81-60 | 4-1 | L. Fletcher 14 | J. Curry 5 | B. Hedrick 6 |
| November 29, 2027 | TENNESSEE STATE TIGERS | W 81-70 | 5-1 | C. Cole 17 | J. Curry 5 | D. McFall 8 |
| December 2, 2027 | MISSISSIPPI VALLEY DELTA DEVILS | W 80-68 | 6-1 | J. Curry 17 | J. Curry 4 | L. Fletcher 7 |
| December 6, 2027 | MORGAN STATE BEARS | W 68-66 | 7-1 | J. Curry 13 | J. Curry 4 | E. Xavier 14 |
| December 13, 2027 | STONY BROOK SEAWOLVES | L 70-78 | 7-2 | J. Curry 14 | E. Xavier 3 | C. Cole 7 |
| December 20, 2027 | GEORGETOWN HOYAS | L 66-73 | 7-3 | C. Cole 12 | J. Curry 4 | D. McFall 7 |
| December 26, 2027 | BOSTON COLLEGE EAGLES* | W 73-61 | 8-3 | L. Fletcher 19 | C. Cole 5 | E. Xavier 11 |
| December 28, 2027 | @ Virginia Tech Hokies* | L 51-65 | 8-4 | J. Curry 14 | J. Curry 3 | E. Xavier 7 |
| January 2, 2028 | @ Florida State Seminoles (8-5, 0-2, 6-2 Home)* | - | | | | |
| January 4, 2028 | CALIFORNIA GOLDEN BEARS (8-3, 2-0, 2-0 Away)* | - | | | | |
| January 9, 2028 | NOTRE DAME FIGHTING IRISH (7-5, 2-0, 2-1 Away)* | - | | | | |
| January 11, 2028 | SOUTHERN METHODIST MUSTANGS (5-7, 0-2, 0-2 Away)* | - | | | | |
| January 16, 2028 | WAKE FOREST DEMON DEACONS (7-4, 1-1, 0-1 Away)* | - | | | | |
| January 18, 2028 | @ Syracuse Orange (3-8, 0-2, 3-7 Home)* | - | | | | |
| January 23, 2028 | DUKE BLUE DEVILS (9-4, 2-0, 1-2 Away)* | - | | | | |
| January 25, 2028 | @ NC-State Wolfpack (5-6, 0-2, 5-5 Home)* | - | | | | |
| January 30, 2028 | NORTH CAROLINA TAR HEELS (11-2, 2-0, 0-0 Away)* | - | | | | |
| February 1, 2028 | @ Stanford Cardinal (10-3, 1-1, 7-2 Home)* | - | | | | |
| February 6, 2028 | LOUISVILLE CARDINALS (11-2, 2-0, 2-0 Away)* | - | | | | |
| February 8, 2028 | @ Georgia Tech Yellow Jackets (10-3, 1-1, 6-0 Home)* | - | | | | |
| February 13, 2028 | @ Pittsburgh Panthers (10-4, 0-2, 7-1 Home)* | - | | | | |
| February 15, 2028 | @ Miami (FL) Hurricanes (6-5, 0-2, 6-0 Home)* | - | | | | |
| February 20, 2028 | @ Virginia Cavaliers (12-1, 2-0, 5-0 Home)* | - | | | | |
| February 22, 2028 | GEORGIA TECH YELLOW JACKETS (10-3, 1-1, 1-3 Away)* | - | | | | |
| February 27, 2028 | @ California Golden Bears (8-3, 2-0, 6-2 Home)* | - | | | | |
| March 1, 2028 | STANFORD CARDINAL (10-3, 1-1, 0-1 Away)* | - | | | | |
