| November 15, 2027 | NORTHWESTERN STATE DEMONS | W 73-52 | 1-0 | R. Kallenberger 20 | E. Johnson 6 | D. Buturovic 13 |
| November 18, 2027 | PENNSYLVANIA QUAKERS | W 81-73 | 2-0 | D. Buturovic 32 | R. Kallenberger 5 | T. Weaver 13 |
| November 22, 2027 | #17 LOUISVILLE CARDINALS | L 86-97 | 2-1 | M. Guiden 29 | R. Kallenberger 7 | D. Buturovic 7 |
| November 25, 2027 | MONMOUTH HAWKS ESPN Events Invitational | W 82-60 | 3-1 | R. Kallenberger 14 | R. Kallenberger 5 | T. Weaver 11 |
| November 26, 2027 | TOLEDO ROCKETS ESPN Events Invitational | W 78-74 | 4-1 | D. Buturovic 20 | M. Guiden 7 | T. Weaver 13 |
| November 27, 2027 | @ #6 West Virginia Mountaineers ESPN Events Invitational | L 77-80 OT | 4-2 | M. Guiden 30 | R. Kallenberger 9 | T. Weaver 14 |
| November 29, 2027 | TENNESSEE-MARTIN SKYHAWKS | W 83-76 | 5-2 | R. Kallenberger 29 | T. Weaver 4 | M. Guiden 8 |
| December 2, 2027 | BOWLING GREEN STATE FALCONS | W 67-62 | 6-2 | M. Guiden 19 | R. Kallenberger 3 | T. Weaver 11 |
| December 6, 2027 | SAN JOSE STATE SPARTANS | W 80-52 | 7-2 | M. Guiden 22 | R. Kallenberger 4 | T. Weaver 9 |
| December 13, 2027 | WYOMING COWBOYS | W 77-60 | 8-2 | M. Guiden 31 | R. Kallenberger 9 | T. Weaver 10 |
| December 20, 2027 | RICE OWLS | W 89-66 | 9-2 | D. Buturovic 20 | R. Kallenberger 7 | T. Weaver 15 |
| December 26, 2027 | XAVIER MUSKETEERS* | W 78-65 | 10-2 | R. Kallenberger 18 | E. Johnson 6 | T. Weaver 14 |
| December 28, 2027 | @ Providence Friars* | L 47-49 | 10-3 | D. Buturovic 13 | R. Kallenberger 4 | T. Weaver 11 |
| December 30, 2027 | @ Seton Hall Pirates* | L 76-84 | 10-4 | D. Buturovic 19 | R. Kallenberger 5 | T. Weaver 8 |
| January 2, 2028 | CONNECTICUT HUSKIES (4-8, 1-1, 0-1 Away)* | - | | | | |
| January 6, 2028 | @ St. Johns Red Storm (7-5, 2-1, 5-2 Home)* | - | | | | |
| January 9, 2028 | @ Villanova Wildcats (10-3, 2-1, 5-1 Home)* | - | | | | |
| January 13, 2028 | MARQUETTE GOLDEN EAGLES (13-1, 2-0, 2-0 Away)* | - | | | | |
| January 16, 2028 | BUTLER BULLDOGS (9-4, 2-0, 2-3 Away)* | - | | | | |
| January 18, 2028 | @ Georgetown Hoyas (9-2, 0-2, 7-1 Home)* | - | | | | |
| January 20, 2028 | @ DePaul Blue Demons (7-4, 0-2, 6-1 Home)* | - | | | | |
| January 25, 2028 | VILLANOVA WILDCATS (10-3, 2-1, 4-1 Away)* | - | | | | |
| February 3, 2028 | @ Xavier Musketeers (6-7, 1-2, 3-4 Home)* | - | | | | |
| February 6, 2028 | @ Connecticut Huskies (4-8, 1-1, 3-6 Home)* | - | | | | |
| February 10, 2028 | SETON HALL PIRATES (10-3, 1-1, 1-1 Away)* | - | | | | |
| February 13, 2028 | PROVIDENCE FRIARS (9-4, 1-1, 1-1 Away)* | - | | | | |
| February 15, 2028 | ST. JOHNS RED STORM (7-5, 2-1, 2-2 Away)* | - | | | | |
| February 22, 2028 | @ Marquette Golden Eagles (13-1, 2-0, 7-1 Home)* | - | | | | |
| February 24, 2028 | @ Butler Bulldogs (9-4, 2-0, 4-1 Home)* | - | | | | |
| March 1, 2028 | DEPAUL BLUE DEMONS (7-4, 0-2, 1-3 Away)* | - | | | | |
| March 3, 2028 | GEORGETOWN HOYAS (9-2, 0-2, 2-1 Away)* | - | | | | |
