| November 15, 2027 | @ Florida State Seminoles | W 89-73 | 1-0 | S. Pryor 21 | A. Cox 8 | C. Bailey 7 |
| November 18, 2027 | BOSTON UNIVERSITY TERRIERS | W 87-79 | 2-0 | S. Pryor 23 | S. Pryor 6 | A. Cox 10 |
| November 22, 2027 | TOLEDO ROCKETS | W 78-60 | 3-0 | A. Cox 18 | S. Pryor 6 | G. Thorne 8 |
| November 25, 2027 | @ Southern Methodist Mustangs | L 69-71 | 3-1 | S. Pryor 18 | A. Cox 4 | A. Cox 7 |
| November 29, 2027 | @ #5 North Carolina Tar Heels | L 60-76 | 3-2 | C. Bailey 21 | B. McCall 3 | B. McCall 7 |
| December 2, 2027 | MARSHALL THUNDERING HERD | W 96-83 | 4-2 | G. Thorne 19 | G. Thorne 3 | G. Thorne 8 |
| December 6, 2027 | INDIANA STATE SYCAMORES | W 86-61 | 5-2 | J. Young 19 | S. Pryor 10 | A. Cox 6 |
| December 13, 2027 | MANHATTAN JASPERS | W 76-71 | 6-2 | J. Young 16 | A. Cox 6 | B. McCall 6 |
| December 20, 2027 | ARMY BLACK KNIGHTS | W 97-67 | 7-2 | J. Young 22 | S. Pryor 6 | B. McCall 12 |
| December 26, 2027 | @ St. Johns Red Storm* | L 84-96 | 7-3 | C. Bailey 22 | A. Cox 6 | C. Bailey 7 |
| December 30, 2027 | BUTLER BULLDOGS* | L 77-81 | 7-4 | C. Bailey 21 | A. Cox 4 | B. McCall 8 |
| January 2, 2028 | @ Villanova Wildcats (10-3, 2-1, 5-1 Home)* | - | | | | |
| January 4, 2028 | @ Georgetown Hoyas (9-2, 0-2, 7-1 Home)* | - | | | | |
| January 6, 2028 | MARQUETTE GOLDEN EAGLES (13-1, 2-0, 2-0 Away)* | - | | | | |
| January 11, 2028 | @ Xavier Musketeers (6-7, 1-2, 3-4 Home)* | - | | | | |
| January 13, 2028 | @ Connecticut Huskies (4-8, 1-1, 3-6 Home)* | - | | | | |
| January 20, 2028 | CREIGHTON BLUE JAYS (10-4, 1-2, 0-2 Away)* | - | | | | |
| January 23, 2028 | GEORGETOWN HOYAS (9-2, 0-2, 2-1 Away)* | - | | | | |
| January 27, 2028 | PROVIDENCE FRIARS (9-4, 1-1, 1-1 Away)* | - | | | | |
| January 30, 2028 | SETON HALL PIRATES (10-3, 1-1, 1-1 Away)* | - | | | | |
| February 1, 2028 | @ Marquette Golden Eagles (13-1, 2-0, 7-1 Home)* | - | | | | |
| February 3, 2028 | @ Butler Bulldogs (9-4, 2-0, 4-1 Home)* | - | | | | |
| February 8, 2028 | CONNECTICUT HUSKIES (4-8, 1-1, 0-1 Away)* | - | | | | |
| February 10, 2028 | XAVIER MUSKETEERS (6-7, 1-2, 2-2 Away)* | - | | | | |
| February 15, 2028 | @ Providence Friars (9-4, 1-1, 5-3 Home)* | - | | | | |
| February 17, 2028 | @ Seton Hall Pirates (10-3, 1-1, 6-2 Home)* | - | | | | |
| February 22, 2028 | VILLANOVA WILDCATS (10-3, 2-1, 4-1 Away)* | - | | | | |
| February 24, 2028 | ST. JOHNS RED STORM (7-5, 2-1, 2-2 Away)* | - | | | | |
| March 1, 2028 | @ Creighton Blue Jays (10-4, 1-2, 8-1 Home)* | - | | | | |
