| November 15, 2027 | DEPAUL BLUE DEMONS | L 73-89 | 0-1 | J. Block 18 | D. Hedrick 3 | G. Montague 7 |
| November 18, 2027 | SOUTHERN ILLINOIS SALUKIS | W 82-81 | 1-1 | J. Block 13 | D. Hedrick 4 | J. Block 9 |
| November 22, 2027 | VALPARAISO BEACONS | W 67-57 | 2-1 | J. Block 11 | D. Hedrick 6 | J. Block 12 |
| November 25, 2027 | EASTERN WASHINGTON EAGLES | W 79-65 | 3-1 | L. Benton 22 | D. Hedrick 5 | J. Block 12 |
| November 29, 2027 | OHIO BOBCATS | W 74-68 | 4-1 | J. Layne 16 | D. Hedrick 4 | B. Forman 6 |
| December 6, 2027 | #18 TEXAS LONGHORNS | L 55-69 | 4-2 | L. Benton 11 | D. Hedrick 2 | J. Block 8 |
| December 9, 2027 | NEBRASKA CORNHUSKERS Jimmy V Classic | W 94-67 | 5-2 | J. Block 25 | D. Hedrick 7 | J. Block 6 |
| December 10, 2027 | @ Houston Cougars Jimmy V Classic | W 79-72 | 6-2 | J. Layne 15 | D. Harris 4 | G. Montague 9 |
| December 11, 2027 | @ Washington State Cougars Jimmy V Classic | L 61-72 | 6-3 | A. Cotton 13 | D. Hedrick 3 | J. Chappel 7 |
| December 13, 2027 | #7 FLORIDA GATORS | W 86-81 | 7-3 | B. Forman 14 | B. Forman 4 | J. Block 5 |
| December 20, 2027 | CALIFORNIA BAPTIST LANCERS | W 69-54 | 8-3 | J. Block 25 | D. Harris 3 | G. Montague 14 |
| December 26, 2027 | @ #11 North Carolina Tar Heels* | L 47-73 | 8-4 | J. Block 10 | J. Block 2 | J. Block 11 |
| December 28, 2027 | @ Wake Forest Demon Deacons* | L 70-79 | 8-5 | G. Montague 14 | D. Hedrick 6 | J. Block 5 |
| January 2, 2028 | CLEMSON TIGERS (8-4, 1-1, 0-1 Away)* | - | | | | |
| January 4, 2028 | NC-STATE WOLFPACK (5-6, 0-2, 0-0 Away)* | - | | | | |
| January 9, 2028 | STANFORD CARDINAL (10-3, 1-1, 0-1 Away)* | - | | | | |
| January 11, 2028 | PITTSBURGH PANTHERS (10-4, 0-2, 0-2 Away)* | - | | | | |
| January 16, 2028 | @ Virginia Cavaliers (12-1, 2-0, 5-0 Home)* | - | | | | |
| January 18, 2028 | BOSTON COLLEGE EAGLES (6-6, 0-2, 0-4 Away)* | - | | | | |
| January 23, 2028 | VIRGINIA TECH HOKIES (7-4, 2-0, 1-1 Away)* | - | | | | |
| January 25, 2028 | GEORGIA TECH YELLOW JACKETS (10-3, 1-1, 1-3 Away)* | - | | | | |
| January 30, 2028 | @ Notre Dame Fighting Irish (7-5, 2-0, 4-3 Home)* | - | | | | |
| February 1, 2028 | @ Southern Methodist Mustangs (5-7, 0-2, 4-4 Home)* | - | | | | |
| February 6, 2028 | CALIFORNIA GOLDEN BEARS (8-3, 2-0, 2-0 Away)* | - | | | | |
| February 8, 2028 | @ Duke Blue Devils (9-4, 2-0, 6-1 Home)* | - | | | | |
| February 13, 2028 | @ Miami (FL) Hurricanes (6-5, 0-2, 6-0 Home)* | - | | | | |
| February 15, 2028 | SYRACUSE ORANGE (3-8, 0-2, 0-0 Away)* | - | | | | |
| February 20, 2028 | LOUISVILLE CARDINALS (11-2, 2-0, 2-0 Away)* | - | | | | |
| February 22, 2028 | @ Syracuse Orange (3-8, 0-2, 3-7 Home)* | - | | | | |
| February 27, 2028 | @ Georgia Tech Yellow Jackets (10-3, 1-1, 6-0 Home)* | - | | | | |
| March 1, 2028 | @ NC-State Wolfpack (5-6, 0-2, 5-5 Home)* | - | | | | |
