| November 15, 2027 | CAL ST. FULLERTON TITANS | W 71-63 | 1-0 | J. Hendrik 21 | J. Hendrik 6 | J. Edwards 7 |
| November 18, 2027 | MARSHALL THUNDERING HERD | W 81-70 | 2-0 | T. Gaskins 14 | J. Hendrik 7 | J. Edwards 9 |
| November 22, 2027 | PURDUE-FORT WAYNE MASTODONS | W 65-58 | 3-0 | J. Hendrik 22 | J. Hendrik 7 | M. Colbert 8 |
| November 25, 2027 | ILLINOIS-CHICAGO FLAMES | W 72-65 | 4-0 | J. Edwards 14 | J. Hendrik 6 | O. Oliver 8 |
| November 29, 2027 | MONTANA GRIZZLIES | W 84-64 | 5-0 | J. Edwards 16 | J. Hendrik 7 | J. Edwards 9 |
| December 2, 2027 | IDAHO STATE BENGALS | W 83-59 | 6-0 | J. Hendrik 17 | J. Edwards 6 | J. Edwards 7 |
| December 6, 2027 | BETHUNE-COOKMAN WILDCATS | W 94-72 | 7-0 | J. Hendrik 26 | J. Edwards 8 | M. Woodley 7 |
| December 13, 2027 | @ Syracuse Orange | W 80-75 | 8-0 | J. Edwards 17 | J. Hendrik 5 | M. Woodley 11 |
| December 20, 2027 | @ Clemson Tigers | W 73-66 | 9-0 | J. Hendrik 17 | J. Hendrik 8 | M. Woodley 9 |
| December 26, 2027 | @ #21 Villanova Wildcats* | L 52-90 | 9-1 | J. Edwards 9 | J. Hendrik 4 | M. Woodley 6 |
| December 30, 2027 | #2 MARQUETTE GOLDEN EAGLES* | L 61-83 | 9-2 | J. Hendrik 15 | J. Hendrik 2 | O. Oliver 9 |
| January 2, 2028 | @ St. Johns Red Storm (7-5, 2-1, 5-2 Home)* | - | | | | |
| January 4, 2028 | DEPAUL BLUE DEMONS (7-4, 0-2, 1-3 Away)* | - | | | | |
| January 6, 2028 | BUTLER BULLDOGS (9-4, 2-0, 2-3 Away)* | - | | | | |
| January 11, 2028 | @ Connecticut Huskies (4-8, 1-1, 3-6 Home)* | - | | | | |
| January 13, 2028 | @ Xavier Musketeers (6-7, 1-2, 3-4 Home)* | - | | | | |
| January 18, 2028 | CREIGHTON BLUE JAYS (10-4, 1-2, 0-2 Away)* | - | | | | |
| January 23, 2028 | @ DePaul Blue Demons (7-4, 0-2, 6-1 Home)* | - | | | | |
| January 27, 2028 | SETON HALL PIRATES (10-3, 1-1, 1-1 Away)* | - | | | | |
| January 30, 2028 | PROVIDENCE FRIARS (9-4, 1-1, 1-1 Away)* | - | | | | |
| February 1, 2028 | @ Butler Bulldogs (9-4, 2-0, 4-1 Home)* | - | | | | |
| February 3, 2028 | @ Marquette Golden Eagles (13-1, 2-0, 7-1 Home)* | - | | | | |
| February 8, 2028 | XAVIER MUSKETEERS (6-7, 1-2, 2-2 Away)* | - | | | | |
| February 10, 2028 | CONNECTICUT HUSKIES (4-8, 1-1, 0-1 Away)* | - | | | | |
| February 15, 2028 | @ Seton Hall Pirates (10-3, 1-1, 6-2 Home)* | - | | | | |
| February 17, 2028 | @ Providence Friars (9-4, 1-1, 5-3 Home)* | - | | | | |
| February 22, 2028 | ST. JOHNS RED STORM (7-5, 2-1, 2-2 Away)* | - | | | | |
| February 24, 2028 | VILLANOVA WILDCATS (10-3, 2-1, 4-1 Away)* | - | | | | |
| March 3, 2028 | @ Creighton Blue Jays (10-4, 1-2, 8-1 Home)* | - | | | | |
