| November 14, 2027 | @ Washington Huskies | W 69-67 | 1-0 | B. Claxton 18 | A. Prince 3 | C. Vines 11 |
| November 18, 2027 | @ Harvard Crimson | L 75-100 | 1-1 | B. Claxton 14 | A. Prince 6 | J. Hannah 10 |
| November 21, 2027 | @ Minnesota Golden Gophers Charleston Classic | L 76-89 | 1-2 | B. Claxton 18 | C. Wheat 7 | C. Vines 10 |
| November 28, 2027 | @ Arkansas Razorbacks | W 81-69 | 2-2 | C. Vines 18 | C. Wheat 6 | C. Vines 13 |
| December 2, 2027 | FLORIDA ATLANTIC OWLS | L 73-74 | 2-3 | C. Vines 20 | A. Prince 4 | C. Vines 8 |
| December 6, 2027 | @ DePaul Blue Demons | L 61-86 | 2-4 | C. Wheat 16 | A. Prince 5 | J. Hannah 12 |
| December 14, 2027 | NORTH FLORIDA OSPREY | L 74-82 | 2-5 | C. Wheat 19 | A. Prince 6 | J. Hannah 8 |
| December 15, 2027 | @ Charleston Southern Buccaneers | L 80-82 | 2-6 | B. Claxton 17 | B. Claxton 3 | B. Claxton 9 |
| December 19, 2027 | @ Erie Freighters | L 66-78 | 2-7 | A. Prince 15 | A. Shepard 3 | C. Vines 8 |
| December 26, 2027 | @ Northern Iowa Panthers* | L 60-80 | 2-8 | A. Prince 17 | A. Prince 3 | C. Vines 11 |
| December 29, 2027 | @ Belmont Bruins* | L 73-91 | 2-9 | B. Claxton 15 | B. Claxton 6 | J. Hannah 8 |
| January 2, 2028 | MISSOURI STATE BEARS (3-9, 0-2, 1-7 Away)* | - | | | | |
| January 5, 2028 | EVANSVILLE PURPLE ACES (5-6, 0-2, 0-6 Away)* | - | | | | |
| January 9, 2028 | MURRAY STATE RACERS (8-3, 2-0, 1-2 Away)* | - | | | | |
| January 12, 2028 | @ Drake Bulldogs (6-6, 2-0, 5-1 Home)* | - | | | | |
| January 16, 2028 | SOUTHERN ILLINOIS SALUKIS (7-4, 2-0, 3-3 Away)* | - | | | | |
| January 19, 2028 | @ Bradley Braves (7-4, 0-2, 4-0 Home)* | - | | | | |
| January 23, 2028 | @ Valparaiso Beacons (3-9, 0-2, 2-1 Home)* | - | | | | |
| January 26, 2028 | @ Southern Illinois Salukis (7-4, 2-0, 4-0 Home)* | - | | | | |
| January 30, 2028 | BRADLEY BRAVES (7-4, 0-2, 3-4 Away)* | - | | | | |
| February 2, 2028 | VALPARAISO BEACONS (3-9, 0-2, 0-7 Away)* | - | | | | |
| February 6, 2028 | DRAKE BULLDOGS (6-6, 2-0, 1-5 Away)* | - | | | | |
| February 9, 2028 | ILLINOIS-CHICAGO FLAMES (4-7, 1-1, 3-7 Away)* | - | | | | |
| February 13, 2028 | @ Missouri State Bears (3-9, 0-2, 1-1 Home)* | - | | | | |
| February 16, 2028 | @ Evansville Purple Aces (5-6, 0-2, 5-0 Home)* | - | | | | |
| February 20, 2028 | NORTHERN IOWA PANTHERS (9-4, 1-1, 2-1 Away)* | - | | | | |
| February 23, 2028 | BELMONT BRUINS (7-5, 2-0, 3-3 Away)* | - | | | | |
| February 27, 2028 | @ Illinois-Chicago Flames (4-7, 1-1, 1-0 Home)* | - | | | | |
| March 2, 2028 | @ Illinois State Redbirds (9-2, 2-0, 4-0 Home)* | - | | | | |
