| November 14, 2027 | @ Richmond Spiders | L 74-85 | 0-1 | J. Clyburn 20 | L. Stanley 7 | J. Curry 7 |
| November 17, 2027 | PRESBYTERIAN BLUE HOSE | W 96-76 | 1-1 | J. Curry 20 | L. Stanley 9 | J. Clyburn 11 |
| November 21, 2027 | GEORGE MASON PATRIOTS WSSN Classic | L 60-72 | 1-2 | J. Clyburn 15 | L. Stanley 3 | L. Stanley 12 |
| November 29, 2027 | @ #1 Marquette Golden Eagles | L 90-104 | 1-3 | J. Curry 22 | L. Evans 3 | L. Stanley 5 |
| December 1, 2027 | ALBANY GREAT DANES | W 72-69 | 2-3 | J. Hogue 16 | J. Hogue 5 | J. Clyburn 7 |
| December 7, 2027 | LIBERTY FLAMES | W 86-79 | 3-3 | L. Stanley 17 | J. Hogue 3 | L. Evans 9 |
| December 13, 2027 | #16 IOWA STATE CYCLONES | L 73-76 | 3-4 | J. Clyburn 17 | L. Stanley 5 | L. Evans 8 |
| December 16, 2027 | MISSISSIPPI STATE BULLDOGS | L 62-66 | 3-5 | J. Curry 12 | J. Clyburn 3 | J. Curry 8 |
| December 21, 2027 | NORTH FLORIDA OSPREY | W 82-64 | 4-5 | J. Clyburn 24 | J. Hogue 7 | J. Clyburn 9 |
| December 26, 2027 | @ Southern California Trojans* | L 60-71 | 4-6 | L. Stanley 12 | L. Stanley 4 | J. Curry 12 |
| December 28, 2027 | #22 UCLA BRUINS* | L 74-81 | 4-7 | J. Clyburn 14 | L. Stanley 5 | L. Stanley 7 |
| January 2, 2028 | @ Northwestern Wildcats (5-6, 0-2, 5-3 Home)* | - | | | | |
| January 4, 2028 | OREGON DUCKS (6-6, 1-1, 0-1 Away)* | - | | | | |
| January 9, 2028 | @ Washington Huskies (7-4, 1-1, 7-2 Home)* | - | | | | |
| January 11, 2028 | INDIANA HOOSIERS (7-4, 2-0, 1-2 Away)* | - | | | | |
| January 16, 2028 | MICHIGAN STATE SPARTANS (9-4, 1-1, 1-2 Away)* | - | | | | |
| January 18, 2028 | OHIO STATE BUCKEYES (7-5, 0-2, 1-3 Away)* | - | | | | |
| January 23, 2028 | @ Maryland Terrapins (9-3, 1-1, 6-0 Home)* | - | | | | |
| January 25, 2028 | MICHIGAN WOLVERINES (12-1, 1-1, 1-1 Away)* | - | | | | |
| January 30, 2028 | @ Purdue Boilermakers (9-3, 2-0, 6-2 Home)* | - | | | | |
| February 1, 2028 | @ Illinois Fighting Illini (8-3, 2-0, 6-1 Home)* | - | | | | |
| February 6, 2028 | @ Nebraska Cornhuskers (5-6, 0-2, 5-2 Home)* | - | | | | |
| February 8, 2028 | @ Penn State Nittany Lions (4-7, 1-1, 4-3 Home)* | - | | | | |
| February 13, 2028 | WISCONSIN BADGERS (10-3, 1-1, 1-2 Away)* | - | | | | |
| February 15, 2028 | RUTGERS SCARLET KNIGHTS (5-7, 0-2, 0-3 Away)* | - | | | | |
| February 20, 2028 | MINNESOTA GOLDEN GOPHERS (9-4, 2-0, 0-2 Away)* | - | | | | |
| February 22, 2028 | @ Michigan State Spartans (9-4, 1-1, 6-1 Home)* | - | | | | |
| February 27, 2028 | SOUTHERN CALIFORNIA TROJANS (8-3, 2-0, 0-0 Away)* | - | | | | |
| March 1, 2028 | @ Wisconsin Badgers (10-3, 1-1, 6-1 Home)* | - | | | | |
