| November 15, 2027 | CANISIUS GOLDEN GRIFFINS | W 80-72 OT | 1-0 | W. Hancock 38 | D. Lee 10 | W. Hancock 15 |
| November 22, 2027 | MARIST RED FOXES | W 60-53 | 2-0 | N. Hancock 15 | D. Lee 4 | W. Hancock 10 |
| November 25, 2027 | BOSTON COLLEGE EAGLES ESPN Events Invitational | L 57-71 | 2-1 | W. Hancock 14 | D. Lee 3 | J. Weathers 6 |
| November 29, 2027 | CALIFORNIA BAPTIST LANCERS | W 82-70 | 3-1 | W. Hancock 21 | D. Lee 5 | W. Hancock 7 |
| December 2, 2027 | XAVIER MUSKETEERS | L 46-73 | 3-2 | D. Lee 10 | D. Lee 5 | W. Hancock 10 |
| December 6, 2027 | @ Houston Cougars | L 48-69 | 3-3 | W. Hancock 15 | D. Lee 2 | C. Dotson 8 |
| December 8, 2027 | DAYTON FLYERS | W 84-69 | 4-3 | D. Lee 19 | D. Lee 3 | J. Weathers 9 |
| December 16, 2027 | SAINT FRANCIS (PA) RED FLASH | W 77-55 | 5-3 | W. Hancock 15 | N. Hancock 4 | W. Hancock 9 |
| December 20, 2027 | @ St. Johns Red Storm | L 76-79 OT | 5-4 | W. Hancock 23 | C. Dotson 4 | J. Weathers 13 |
| December 26, 2027 | #18 MARYLAND TERRAPINS* | L 57-75 | 5-5 | W. Hancock 12 | D. Lee 5 | N. Hancock 5 |
| December 28, 2027 | ILLINOIS FIGHTING ILLINI* | L 59-75 | 5-6 | N. Hancock 18 | D. Lee 8 | C. Dotson 8 |
| January 2, 2028 | IOWA HAWKEYES (4-7, 0-2, 0-3 Away)* | - | | | | |
| January 4, 2028 | WISCONSIN BADGERS (10-3, 1-1, 1-2 Away)* | - | | | | |
| January 9, 2028 | @ Purdue Boilermakers (9-3, 2-0, 6-2 Home)* | - | | | | |
| January 11, 2028 | MICHIGAN WOLVERINES (12-1, 1-1, 1-1 Away)* | - | | | | |
| January 16, 2028 | @ Washington Huskies (7-4, 1-1, 7-2 Home)* | - | | | | |
| January 18, 2028 | @ Indiana Hoosiers (7-4, 2-0, 6-1 Home)* | - | | | | |
| January 23, 2028 | OREGON DUCKS (6-6, 1-1, 0-1 Away)* | - | | | | |
| January 25, 2028 | SOUTHERN CALIFORNIA TROJANS (8-3, 2-0, 0-0 Away)* | - | | | | |
| January 30, 2028 | @ UCLA Bruins (10-3, 1-1, 6-2 Home)* | - | | | | |
| February 1, 2028 | RUTGERS SCARLET KNIGHTS (5-7, 0-2, 0-3 Away)* | - | | | | |
| February 6, 2028 | @ Minnesota Golden Gophers (9-4, 2-0, 7-1 Home)* | - | | | | |
| February 8, 2028 | @ Ohio State Buckeyes (7-5, 0-2, 5-1 Home)* | - | | | | |
| February 13, 2028 | @ Nebraska Cornhuskers (5-6, 0-2, 5-2 Home)* | - | | | | |
| February 15, 2028 | PENN STATE NITTANY LIONS (4-7, 1-1, 0-3 Away)* | - | | | | |
| February 20, 2028 | @ Michigan State Spartans (9-4, 1-1, 6-1 Home)* | - | | | | |
| February 22, 2028 | OHIO STATE BUCKEYES (7-5, 0-2, 1-3 Away)* | - | | | | |
| February 27, 2028 | @ Michigan Wolverines (12-1, 1-1, 8-0 Home)* | - | | | | |
| March 1, 2028 | @ Rutgers Scarlet Knights (5-7, 0-2, 4-3 Home)* | - | | | | |
