| November 14, 2027 | @ Southern Methodist Mustangs | L 66-86 | 0-1 | D. Chapman 15 | J. Cobb 4 | D. Chapman 9 |
| November 18, 2027 | @ #7 Louisville Cardinals | L 63-80 | 0-2 | J. Cobb 12 | J. Chatman 7 | E. Hancock 7 |
| November 21, 2027 | @ Missouri Tigers WSSN Classic | L 59-71 | 0-3 | J. Best 14 | J. Chatman 3 | J. Cobb 10 |
| November 24, 2027 | @ Grambling Tigers | W 87-76 | 1-3 | J. Chatman 22 | J. Chatman 8 | J. Best 7 |
| November 29, 2027 | @ Florida State Seminoles | L 68-74 | 1-4 | J. Chatman 13 | J. Chatman 6 | D. Chapman 9 |
| December 1, 2027 | @ California Baptist Lancers | W 85-77 | 2-4 | J. Chatman 18 | J. Cobb 6 | D. Lofton 6 |
| December 5, 2027 | MASSACHUSETTS MINUTEMEN | W 84-72 | 3-4 | E. Hancock 22 | J. Chatman 8 | E. Hancock 10 |
| December 8, 2027 | ORAL ROBERTS GOLDEN EAGLES | W 72-51 | 4-4 | E. Hancock 16 | J. Chatman 5 | E. Hancock 9 |
| December 21, 2027 | SIENA SAINTS | W 81-66 | 5-4 | D. Chapman 18 | J. Cobb 4 | E. Hancock 8 |
| December 26, 2027 | @ Akron Zips* | L 68-89 | 5-5 | D. Lofton 13 | J. Chatman 3 | J. Cobb 5 |
| December 29, 2027 | @ Western Michigan Broncos* | L 76-81 | 5-6 | D. Lofton 24 | J. Cobb 8 | E. Hancock 7 |
| January 2, 2028 | EASTERN MICHIGAN EAGLES (6-5, 1-1, 2-4 Away)* | - | | | | |
| January 5, 2028 | NORTHERN ILLINOIS HUSKIES (8-3, 1-1, 2-2 Away)* | - | | | | |
| January 9, 2028 | MIAMI (OH) REDHAWKS (6-5, 2-0, 2-5 Away)* | - | | | | |
| January 12, 2028 | @ Buffalo Bulls (1-10, 0-2, 0-1 Home)* | - | | | | |
| January 16, 2028 | @ Central Michigan Chippewas (4-7, 0-2, 2-0 Home)* | - | | | | |
| January 19, 2028 | TOLEDO ROCKETS (6-6, 1-1, 4-5 Away)* | - | | | | |
| January 23, 2028 | KENT STATE GOLDEN FLASHES (8-4, 1-1, 1-3 Away)* | - | | | | |
| January 26, 2028 | @ Ball State Cardinals (4-7, 0-2, 2-1 Home)* | - | | | | |
| January 30, 2028 | @ Toledo Rockets (6-6, 1-1, 1-0 Home)* | - | | | | |
| February 2, 2028 | @ Kent State Golden Flashes (8-4, 1-1, 6-0 Home)* | - | | | | |
| February 6, 2028 | BUFFALO BULLS (1-10, 0-2, 1-8 Away)* | - | | | | |
| February 9, 2028 | CENTRAL MICHIGAN CHIPPEWAS (4-7, 0-2, 2-7 Away)* | - | | | | |
| February 13, 2028 | @ Eastern Michigan Eagles (6-5, 1-1, 4-1 Home)* | - | | | | |
| February 16, 2028 | @ Northern Illinois Huskies (8-3, 1-1, 6-1 Home)* | - | | | | |
| February 20, 2028 | AKRON ZIPS (7-4, 2-0, 0-2 Away)* | - | | | | |
| February 23, 2028 | WESTERN MICHIGAN BRONCOS (4-7, 2-0, 0-6 Away)* | - | | | | |
| February 27, 2028 | BALL STATE CARDINALS (4-7, 0-2, 2-6 Away)* | - | | | | |
| March 2, 2028 | @ Bowling Green State Falcons (7-4, 2-0, 5-0 Home)* | - | | | | |
