| November 14, 2027 | @ Army Black Knights | L 75-82 | 0-1 | L. Adams 26 | M. Thornton 6 | M. Driesell 9 |
| November 17, 2027 | @ Citadel Bulldogs | L 71-80 | 0-2 | L. Adams 21 | M. Thornton 5 | V. Xavier 10 |
| November 22, 2027 | @ Southern Mississippi Golden Eagles | W 88-82 | 1-2 | W. Kickert 17 | L. Adams 6 | M. Driesell 7 |
| November 24, 2027 | WESTERN MICHIGAN BRONCOS | W 79-57 | 2-2 | L. Adams 22 | M. Deane 6 | V. Xavier 7 |
| November 28, 2027 | @ Nebraska Cornhuskers | L 75-80 | 2-3 | M. Driesell 19 | L. Adams 5 | V. Xavier 9 |
| December 1, 2027 | @ Kent State Golden Flashes | L 66-74 | 2-4 | L. Adams 16 | M. Thornton 2 | L. Adams 9 |
| December 5, 2027 | @ UC-Riverside Highlanders | L 58-72 | 2-5 | L. Adams 20 | M. Thornton 7 | V. Xavier 10 |
| December 8, 2027 | NJIT HIGHLANDERS | W 92-78 | 3-5 | L. Adams 18 | M. Thornton 6 | M. Driesell 10 |
| December 12, 2027 | @ Lehigh Mountain Hawks | L 74-75 | 3-6 | L. Adams 27 | M. Thornton 6 | M. Deane 9 |
| December 15, 2027 | WRIGHT STATE RAIDERS | W 92-69 | 4-6 | M. Driesell 22 | B. Sarpy 4 | M. Driesell 8 |
| December 19, 2027 | HARVARD CRIMSON | L 81-89 | 4-7 | L. Adams 18 | M. Deane 5 | V. Xavier 11 |
| December 22, 2027 | @ Bryant Bulldogs | L 81-85 | 4-8 | L. Adams 17 | M. Driesell 4 | M. Driesell 12 |
| December 26, 2027 | BELLARMINE KNIGHTS | W 83-76 | 5-8 | M. Thornton 23 | M. Thornton 8 | M. Driesell 9 |
| January 2, 2028 | SO. CAROLINA UPSTATE SPARTANS (5-8, 0-0, 2-8 Away)* | - | | | | |
| January 5, 2028 | @ High Point Panthers (5-8, 0-0, 3-2 Home)* | - | | | | |
| January 9, 2028 | NC-ASHEVILLE BULLDOGS (7-6, 0-0, 1-6 Away)* | - | | | | |
| January 12, 2028 | @ Longwood Lancers (6-7, 0-0, 2-2 Home)* | - | | | | |
| January 16, 2028 | GARDNER-WEBB RUNNIN' BULLDOGS (3-10, 0-0, 2-7 Away)* | - | | | | |
| January 23, 2028 | @ Winthrop Eagles (3-10, 0-0, 0-2 Home)* | - | | | | |
| January 26, 2028 | CHARLESTON SOUTHERN BUCCANEERS (7-6, 0-0, 3-5 Away)* | - | | | | |
| January 30, 2028 | @ Presbyterian Blue Hose (4-9, 0-0, 3-3 Home)* | - | | | | |
| February 2, 2028 | @ So. Carolina Upstate Spartans (5-8, 0-0, 3-0 Home)* | - | | | | |
| February 6, 2028 | HIGH POINT PANTHERS (5-8, 0-0, 2-6 Away)* | - | | | | |
| February 9, 2028 | @ NC-Asheville Bulldogs (7-6, 0-0, 6-0 Home)* | - | | | | |
| February 13, 2028 | LONGWOOD LANCERS (6-7, 0-0, 4-5 Away)* | - | | | | |
| February 16, 2028 | @ Gardner-Webb Runnin' Bulldogs (3-10, 0-0, 1-3 Home)* | - | | | | |
| February 23, 2028 | WINTHROP EAGLES (3-10, 0-0, 3-8 Away)* | - | | | | |
| February 27, 2028 | @ Charleston Southern Buccaneers (7-6, 0-0, 4-1 Home)* | - | | | | |
| March 2, 2028 | PRESBYTERIAN BLUE HOSE (4-9, 0-0, 1-6 Away)* | - | | | | |
