| November 15, 2027 | OKLAHOMA SOONERS | L 67-71 | 0-1 | J. James 19 | J. James 7 | T. Jefferson 7 |
| November 18, 2027 | @ Minnesota Golden Gophers | L 83-90 | 0-2 | J. James 21 | J. James 6 | T. Jefferson 8 |
| November 22, 2027 | RIDER BRONCS | W 69-50 | 1-2 | M. Neeser 23 | M. Neeser 3 | T. Jefferson 13 |
| November 29, 2027 | @ Arizona State Sun Devils | W 81-72 | 2-2 | E. Roland 19 | M. Satchell 4 | B. Williams 9 |
| December 2, 2027 | @ Northwestern Wildcats | W 73-46 | 3-2 | J. James 28 | M. Neeser 7 | T. Jefferson 11 |
| December 6, 2027 | FURMAN PALADINS | W 66-49 | 4-2 | J. Poge 14 | J. James 5 | B. Williams 9 |
| December 13, 2027 | #14 CINCINNATI BEARCATS | L 66-76 | 4-3 | M. Satchell 17 | J. James 9 | M. Satchell 8 |
| December 16, 2027 | CHARLOTTE 49ERS Battle 4 Atlantis | W 67-59 | 5-3 | J. James 21 | J. James 5 | T. Jefferson 13 |
| December 17, 2027 | @ Wisconsin Badgers Battle 4 Atlantis | L 74-83 | 5-4 | J. James 19 | J. James 8 | J. James 5 |
| December 20, 2027 | SAN JOSE STATE SPARTANS | L 65-67 | 5-5 | J. James 18 | E. Roland 3 | J. James 8 |
| December 26, 2027 | @ #16 Creighton Blue Jays* | L 65-78 | 5-6 | J. James 16 | J. James 5 | B. Williams 9 |
| December 28, 2027 | #21 VILLANOVA WILDCATS* | L 61-81 | 5-7 | M. Neeser 12 | B. Williams 3 | B. Williams 7 |
| December 30, 2027 | ST. JOHNS RED STORM* | W 76-57 | 6-7 | B. Williams 19 | J. James 5 | T. Jefferson 7 |
| January 4, 2028 | @ Marquette Golden Eagles (13-1, 2-0, 7-1 Home)* | - | | | | |
| January 11, 2028 | DEPAUL BLUE DEMONS (7-4, 0-2, 1-3 Away)* | - | | | | |
| January 13, 2028 | GEORGETOWN HOYAS (9-2, 0-2, 2-1 Away)* | - | | | | |
| January 20, 2028 | @ Seton Hall Pirates (10-3, 1-1, 6-2 Home)* | - | | | | |
| January 23, 2028 | @ Providence Friars (9-4, 1-1, 5-3 Home)* | - | | | | |
| January 25, 2028 | BUTLER BULLDOGS (9-4, 2-0, 2-3 Away)* | - | | | | |
| January 27, 2028 | MARQUETTE GOLDEN EAGLES (13-1, 2-0, 2-0 Away)* | - | | | | |
| February 1, 2028 | CONNECTICUT HUSKIES (4-8, 1-1, 0-1 Away)* | - | | | | |
| February 3, 2028 | CREIGHTON BLUE JAYS (10-4, 1-2, 0-2 Away)* | - | | | | |
| February 8, 2028 | @ Georgetown Hoyas (9-2, 0-2, 7-1 Home)* | - | | | | |
| February 10, 2028 | @ DePaul Blue Demons (7-4, 0-2, 6-1 Home)* | - | | | | |
| February 15, 2028 | @ Connecticut Huskies (4-8, 1-1, 3-6 Home)* | - | | | | |
| February 17, 2028 | @ Butler Bulldogs (9-4, 2-0, 4-1 Home)* | - | | | | |
| February 22, 2028 | SETON HALL PIRATES (10-3, 1-1, 1-1 Away)* | - | | | | |
| February 24, 2028 | PROVIDENCE FRIARS (9-4, 1-1, 1-1 Away)* | - | | | | |
| March 1, 2028 | @ St. Johns Red Storm (7-5, 2-1, 5-2 Home)* | - | | | | |
| March 3, 2028 | @ Villanova Wildcats (10-3, 2-1, 5-1 Home)* | - | | | | |
