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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saidana, Omar | RP | Augusta GreenJackets | 21 | 04/14/2005 | Long Beach | USA | Right | Right | 6' 0" | 175 lbs | - |
| Salazar, Edgar | RF | Carolina Mudcats | 24 | 06/24/2002 | Oklahoma City | USA | Right | Right | 6' 4" | 220 lbs | - |
| Sales, Josh | C | Salem Red Sox | 22 | 11/11/2003 | The Acreage | USA | Right | Right | 6' 0" | 200 lbs | - |
| Sanchez, Albert | 2B | Charleston RiverDogs | 20 | 08/24/2006 | Santo Domingo | DOM | Right | Right | 5' 10" | 170 lbs | - |
| Sanchez, Raul | RP | Myrtle Beach Pelicans | 20 | 09/27/2005 | Castaic | USA | Left | Left | 6' 1" | 180 lbs | - |
| Sanchez, Ricky | RP | Salem Red Sox | 20 | 01/13/2006 | Santo Domingo | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Sandoval, Willie | 3B | Columbia Fireflies | 22 | 09/05/2004 | Santo Domingo | DOM | Right | Right | 6' 1" | 200 lbs | - |
| Santana, Dennis | LF | Free Agent | 24 | 03/09/2002 | Aloha | USA | Right | Right | 6' 0" | 195 lbs | - |
| Schmitt, Erik | SS | Down East Wood Ducks | 21 | 10/26/2004 | El Paso | USA | Right | Right | 6' 4" | 215 lbs | - |
| Schreiber, Karl | 1B | Lynchburg Hillcats | 23 | 03/28/2003 | LaPlace | USA | Right | Right | 6' 2" | 210 lbs | - |
| Scott, Danny | 2B | Delmarva Shorebirds | 24 | 06/03/2002 | Glendora | USA | Right | Right | 6' 0" | 185 lbs | - |
| Scott, Mike | RP | Charleston RiverDogs | 23 | 12/10/2002 | Lochearn | USA | Right | Right | 6' 1" | 195 lbs | - |
| Segura, Jose | 3B | Myrtle Beach Pelicans | 20 | 03/14/2006 | Colón | PAN | Left | Right | 6' 2" | 190 lbs | - |
| Seidel, Kyle | SP | Fredericksburg Nationals | 18 | 03/27/2008 | Estelle | USA | Right | Right | 5' 11" | 170 lbs | - |
| Shadrick, Glenn | SP | Down East Wood Ducks | 23 | 02/20/2003 | Camanche | USA | Right | Right | 6' 2" | 195 lbs | - |
| Shafer, Mike | CF | Augusta GreenJackets | 19 | 05/07/2007 | Vineyard | USA | Left | Right | 6' 2" | 180 lbs | - |
| Shaffer, Matt | SP | Salem Red Sox | 22 | 05/15/2004 | Clarksville | USA | Right | Right | 6' 1" | 185 lbs | - |
| Shaker, Mike | 2B | Fredericksburg Nationals | 21 | 06/28/2005 | Sheldon | USA | Right | Right | 5' 9" | 165 lbs | - |
| Shearer, Jeremy | RP | Salem Red Sox | 20 | 01/23/2006 | Peachtree City | USA | Right | Right | 6' 0" | 175 lbs | - |
| Simmons, Steve | SP | Columbia Fireflies | 24 | 08/11/2002 | Hobart | USA | Left | Left | 6' 2" | 200 lbs | - |
| Skelton, Greg | LF | Free Agent | 24 | 02/02/2002 | Catlin | USA | Left | Left | 6' 1" | 200 lbs | - |
| Smith, Aaron | SP | Down East Wood Ducks | 18 | 05/19/2008 | Taylorsville | USA | Switch | Right | 6' 2" | 180 lbs | - |
| Smith, Brad | RP | Lynchburg Hillcats | 19 | 12/08/2006 | Anaheim | USA | Right | Right | 5' 10" | 165 lbs | - |
| Smith, Jimmy | 3B | Lynchburg Hillcats | 19 | 10/01/2006 | Uhrichsville | USA | Switch | Right | 6' 0" | 175 lbs | - |
| Snyder, Mike | RP | Fredericksburg Nationals | 22 | 10/04/2003 | Aurora | USA | Right | Right | 6' 0" | 185 lbs | - |
| Snyder, Pete | SP | Carolina Mudcats | 20 | 06/14/2006 | Lakewood | USA | Right | Right | 6' 2" | 190 lbs | - |
| Soria, John | CL | Myrtle Beach Pelicans | 23 | 06/16/2003 | Crown Point | USA | Left | Left | 6' 4" | 210 lbs | - |
| Sospiri, Gaetan | RP | Carolina Mudcats | 21 | 08/18/2005 | Barquisimeto | VEN | Left | Left | 6' 4" | 200 lbs | - |
| Sponaugle, Seth | 1B | Delmarva Shorebirds | 19 | 02/24/2007 | North Port | USA | Left | Left | 6' 4" | 210 lbs | - |
| St. Dennis, Cody | CF | Kannapolis Cannon Ballers | 22 | 11/03/2003 | Clarion | USA | Right | Right | 6' 0" | 205 lbs | - |
| Stack, Brad | C | Columbia Fireflies | 24 | 07/29/2002 | Kansas City | USA | Switch | Right | 6' 0" | 215 lbs | - |
| Stanton, Erick | RP | Salem Red Sox | 22 | 12/26/2003 | Chula Vista | USA | Right | Right | 6' 0" | 190 lbs | - |
| Steffe, Jared | RF | Lynchburg Hillcats | 23 | 12/06/2002 | Siler | USA | Right | Right | 6' 0" | 200 lbs | - |
| Stein, Dan | 1B | Kannapolis Cannon Ballers | 21 | 03/26/2005 | New York | USA | Right | Right | 6' 6" | 240 lbs | - |
