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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saathoff, Jason | C | Round Rock Express | 22 | 05/18/2004 | Waterford Township | USA | Right | Right | 6' 1" | 215 lbs | - |
| Salinas, John | RP | Albuquerque Isotopes | 22 | 12/26/2003 | Santo Domingo | DOM | Right | Right | 6' 0" | 195 lbs | - |
| Sanchez, Jon | 1B | Sacramento River Cats | 25 | 08/13/2000 | North Olmsted | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sanchez, Jose | RP | Reno Aces | 24 | 01/26/2002 | Seven Trees | USA | Right | Right | 6' 2" | 195 lbs | - |
| Santo, Tyler | RP | Sacramento River Cats | 23 | 10/30/2002 | Charlotte | USA | Right | Right | 6' 1" | 195 lbs | - |
| Santorio, Gautier | SP | Reno Aces | 25 | 12/29/2000 | Canicattì | ITA | Left | Left | 5' 11" | 190 lbs | $3,800,000 |
| Santos, Alberto | CF | Tacoma Rainiers | 24 | 11/06/2001 | Jacksonville | USA | Switch | Left | 6' 1" | 200 lbs | $2,200,000 |
| Sarmiento, Alex | RF | Sugar Land Skeeters | 24 | 09/23/2001 | Santo Domingo | DOM | Right | Right | 5' 11" | 185 lbs | $1,900,000 |
| Schultz, Steve | 1B | El Paso Chihuahuas | 24 | 10/02/2001 | Mesa | USA | Right | Left | 6' 1" | 195 lbs | - |
| Schwartz, Joe | RP | Tacoma Rainiers | 28 | 11/21/1997 | Opportunity | USA | Left | Left | 5' 11" | 190 lbs | $740,000 |
| Scott, Andre | RF | Salt Lake Bees | 24 | 04/08/2002 | South Taft | USA | Right | Right | 6' 1" | 205 lbs | - |
| Scudder, Ian | 2B | Salt Lake Bees | 25 | 05/10/2001 | Seabrook | USA | Right | Right | 6' 0" | 190 lbs | $740,000 |
| Seals, Jon | RF | Free Agent | 28 | 05/12/1998 | Markham | USA | Switch | Right | 6' 1" | 205 lbs | - |
| Sebuggwawo, Salah | RP | Salt Lake Bees | 22 | 07/16/2003 | Dakar | SEN | Right | Right | 5' 9" | 165 lbs | - |
| Segura, Juan | SP | Free Agent | 27 | 03/19/1999 | Esperanza | DOM | Right | Right | 6' 4" | 210 lbs | - |
| Seligman, Bob | RP | Tacoma Rainiers | 25 | 05/01/2001 | Hernando | USA | Right | Right | 6' 2" | 205 lbs | - |
| Serna, Joel | RP | El Paso Chihuahuas | 25 | 01/11/2001 | Santo Domingo | DOM | Right | Right | 6' 3" | 200 lbs | $2,400,000 |
| Settles, Bill | SP | Las Vegas Aviators | 27 | 05/04/1999 | Barstow | USA | Right | Right | 5' 10" | 195 lbs | - |
| Shaw, Brenden | RF | Las Vegas Aviators | 26 | 12/19/1999 | Landover Hills | USA | Left | Left | 5' 10" | 195 lbs | - |
| Sims, Brian | SP | Round Rock Express | 25 | 06/08/2001 | New York | USA | Right | Right | 6' 3" | 205 lbs | - |
| Slater, Toby | SS | Las Vegas Aviators | 25 | 04/05/2001 | Brisbane | AUS | Left | Right | 6' 0" | 190 lbs | - |
| Slaughter, Josh | 2B | Reno Aces | 27 | 06/04/1999 | Irondequoit | USA | Right | Right | 6' 0" | 185 lbs | $740,000 |
| Smallwood, Chris | RF | Tacoma Rainiers | 26 | 01/21/2000 | Ballwin | USA | Right | Right | 6' 1" | 205 lbs | $3,200,000 |
| Smart, Greg | LF | Round Rock Express | 25 | 10/26/2000 | Gatesville | USA | Right | Left | 6' 1" | 200 lbs | $740,000 |
| Smith, Cameron | RP | Free Agent | 29 | 06/17/1996 | Brumley | USA | Left | Left | 6' 0" | 200 lbs | - |
| Smith, Matt | RP | Sugar Land Skeeters | 22 | 08/28/2003 | Exeter | USA | Right | Right | 6' 0" | 185 lbs | - |
| Solis, Luis | RP | Round Rock Express | 25 | 11/01/2000 | San Francisco de Macorís | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Solorzano, Edgar | C | El Paso Chihuahuas | 24 | 10/24/2001 | Wichita | USA | Left | Right | 6' 3" | 230 lbs | $2,000,000 |
| Solt, Joey | RP | Free Agent | 20 | 09/06/2005 | Estes Park | USA | Switch | Right | 5' 11" | 170 lbs | - |
| Soto, Gus | SS | Sugar Land Skeeters | 22 | 12/12/2003 | South Beloit | USA | Right | Right | 6' 2" | 185 lbs | - |
| Stack, Mike | CF | Las Vegas Aviators | 23 | 08/28/2002 | Upper Arlington | USA | Left | Left | 6' 1" | 195 lbs | - |
| Stout, Rich | RP | Sugar Land Skeeters | 22 | 05/31/2004 | Hampton Township | USA | Left | Right | 6' 4" | 200 lbs | - |
| Suarez, Jose | CF | Las Vegas Aviators | 24 | 10/08/2001 | San Cristóbal | DOM | Left | Right | 6' 1" | 195 lbs | - |
| Swanson, Jim | SP | Sacramento River Cats | 21 | 12/01/2004 | Denver | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Sweet, Corey | C | Las Vegas Aviators | 24 | 01/31/2002 | New York | USA | Switch | Right | 6' 1" | 205 lbs | - |
| Syner, Sam | LF | Free Agent | 27 | 10/04/1998 | Palmview | USA | Switch | Right | 6' 0" | 205 lbs | - |
