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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saavedra, Jon | RP | Hudson Valley Renegades | 21 | 12/30/2004 | Sandy Springs | USA | Right | Right | 5' 10" | 175 lbs | - |
| Sabino, Sergio | SP | Brooklyn Cyclones | 22 | 10/10/2003 | La Romana | DOM | Right | Right | 5' 11" | 185 lbs | - |
| Salas, Cesar | CF | Greensboro Grasshoppers | 17 | 02/10/2009 | Guatire | VEN | Right | Left | 6' 2" | 180 lbs | - |
| Saldana, Bill | RP | Hickory Crawdads | 21 | 08/19/2004 | San Juan | PUR | Left | Left | 6' 1" | 190 lbs | - |
| Salmeron, Juan | SP | Hudson Valley Renegades | 24 | 01/22/2002 | La Romana | DOM | Left | Left | 6' 0" | 190 lbs | - |
| Saloom, J.D. | SP | Hickory Crawdads | 22 | 07/14/2003 | Bay Point | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sanchez, Hugo | 1B | Greensboro Grasshoppers | 22 | 06/25/2003 | Alexandria | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sanchez, Nick | RP | Hudson Valley Renegades | 20 | 09/26/2005 | Lima | USA | Right | Right | 6' 0" | 180 lbs | - |
| Sandoval, Estevan | CF | Asheville Tourists | 21 | 09/17/2004 | Oakland | USA | Right | Right | 6' 1" | 180 lbs | - |
| Santana, Manny | 1B | Greensboro Grasshoppers | 22 | 06/28/2003 | Fruit Cove | USA | Right | Right | 6' 2" | 220 lbs | - |
| Santiago, Antonio | 3B | Free Agent | 23 | 07/30/2002 | Willemstad | CUR | Right | Right | 6' 2" | 190 lbs | - |
| Santiago, Jonathan | LF | Aberdeen Ironbirds | 22 | 11/17/2003 | Arvada | USA | Left | Left | 6' 2" | 210 lbs | - |
| Santoyo, Ruben | SP | Rome Braves | 17 | 10/01/2008 | Villa Jaragua | DOM | Switch | Right | 6' 0" | 180 lbs | - |
| Sawyer, Matt | RP | Aberdeen Ironbirds | 21 | 11/10/2004 | Dearborn | USA | Left | Left | 6' 1" | 190 lbs | - |
| Schlabach, Jerry | 2B | Aberdeen Ironbirds | 23 | 09/12/2002 | Barstow | USA | Right | Right | 6' 2" | 195 lbs | - |
| Schlundt, Matt | 1B | Rome Braves | 19 | 09/11/2006 | Millville | USA | Right | Right | 6' 1" | 180 lbs | - |
| Schweikert, Bob | RP | Aberdeen Ironbirds | 21 | 02/11/2005 | Silver Spring | USA | Left | Left | 5' 9" | 160 lbs | - |
| Schwerdtfeger, Jason | 3B | Winston-Salem Dash | 23 | 04/13/2003 | Downingtown | USA | Switch | Right | 6' 0" | 195 lbs | - |
| Scioscia, Kevin | RP | Jersey Shore BlueClaws | 23 | 06/29/2002 | Anaheim | USA | Right | Right | 6' 2" | 205 lbs | - |
| Segal, Travis | RP | Hudson Valley Renegades | 20 | 10/03/2005 | San Antonio | USA | Right | Right | 6' 0" | 185 lbs | - |
| Segundo, Javy | SP | Brooklyn Cyclones | 23 | 04/06/2003 | Santo Domingo | DOM | Right | Left | 6' 2" | 195 lbs | - |
| Shafer, Mike | CF | Rome Braves | 19 | 05/07/2007 | Vineyard | USA | Left | Right | 6' 2" | 180 lbs | - |
| Shaffer, Jeff | 1B | Free Agent | 23 | 05/21/2003 | Glenvar Heights | USA | Left | Left | 6' 2" | 205 lbs | - |
| Sheppard, Justin | 3B | Free Agent | 26 | 03/29/2000 | Fort Worth | USA | Right | Right | 6' 0" | 215 lbs | - |
| Shields, John | C | Free Agent | 24 | 09/14/2001 | North Miami | USA | Right | Right | 5' 10" | 195 lbs | - |
| Shilvock, John | 3B | Hudson Valley Renegades | 19 | 12/05/2006 | Brampton | CAN | Left | Right | 6' 1" | 195 lbs | - |
| Sidwell, Perry | SP | Asheville Tourists | 24 | 03/10/2002 | Troy | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sieczka, Ben | LF | Bowling Green Hot Rods | 21 | 07/13/2004 | Upper Arlington | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sierra, Daniel | RP | Hickory Crawdads | 22 | 12/12/2003 | Temblador | VEN | Left | Left | 5' 9" | 170 lbs | - |
| Sigala, Danny | 3B | Rome Braves | 19 | 10/18/2006 | Santo Domingo | DOM | Right | Right | 6' 1" | 190 lbs | - |
| Silva, Carlos | RP | Free Agent | 25 | 05/25/2001 | Barquisimeto | VEN | Right | Right | 6' 0" | 195 lbs | - |
| Smalls, Jabari | SS | Wilmington Blue Rocks | 19 | 12/26/2006 | Hornellsville | USA | Right | Right | 6' 0" | 185 lbs | - |
| Smeltzer, Ronnie | RP | Asheville Tourists | 20 | 02/19/2006 | West Haven | USA | Right | Right | 6' 1" | 180 lbs | - |
| Smith, Alex | 3B | Free Agent | 25 | 01/31/2001 | Lake Worth | USA | Right | Right | 6' 2" | 200 lbs | - |
| Smith, Chris | 1B | Bowling Green Hot Rods | 24 | 09/12/2001 | New York | USA | Right | Right | 6' 0" | 205 lbs | $2,400,000 |
| Smith, Gabe | CL | Greensboro Grasshoppers | 22 | 11/28/2003 | Tysons | USA | Switch | Right | 6' 2" | 200 lbs | - |
| Smith, Kasey | C | Asheville Tourists | 24 | 01/03/2002 | Ridgefield Park | USA | Right | Right | 6' 0" | 200 lbs | - |
| Smith, Shane | RP | Free Agent | 25 | 02/14/2001 | Vandalia | USA | Right | Right | 5' 10" | 185 lbs | - |
| Smith, Zack | RP | Free Agent | 25 | 08/08/2000 | Elk Plain | USA | Left | Left | 5' 10" | 190 lbs | - |
| Somoza, Raul | RF | Hickory Crawdads | 21 | 12/31/2004 | Greenfield Township (Lackawanna County) | USA | Switch | Right | 6' 1" | 200 lbs | - |
| Sotelo, Jordan | 2B | Free Agent | 24 | 01/20/2002 | Baníca | DOM | Right | Right | 6' 1" | 185 lbs | - |
| Soto, Cesar | RP | Winston-Salem Dash | 22 | 12/28/2003 | Santo Domingo | DOM | Switch | Right | 6' 1" | 195 lbs | - |
| Southerland, Rich | SP | Rome Braves | 19 | 09/22/2006 | Fulshear | USA | Right | Right | 6' 1" | 185 lbs | - |
| Spooner, Chris | SS | Bowling Green Hot Rods | 20 | 01/11/2006 | St. Paul | USA | Right | Right | 6' 0" | 165 lbs | - |
| Stanford, Jay | SP | Hudson Valley Renegades | 20 | 05/07/2006 | Columbia | USA | Right | Right | 6' 1" | 185 lbs | - |
| Sullins, Walt | RP | Greensboro Grasshoppers | 20 | 08/05/2005 | Pleasure Ridge Park | USA | Right | Right | 6' 2" | 190 lbs | - |
| Summitt, Greg | LF | Hickory Crawdads | 20 | 11/13/2005 | West Norriton | USA | Right | Right | 6' 1" | 185 lbs | - |
| Sutherland, Ken | 1B | Hickory Crawdads | 18 | 11/21/2007 | Tucson | USA | Left | Right | 5' 11" | 165 lbs | - |
